文章基本信息

标题：Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL
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作者：Nirupa R. Matthan ; Ann Giovanni ; Ernst J. Schaefer 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2003
卷号：44
期号：4
页码：800-806
DOI：10.1194/jlr.M200439-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The HDL Atherosclerosis Treatment Study (HATS) demonstrated a clinical benefit in coronary artery disease patients with low HDL cholesterol (HDL-C) levels treated with simvastatin and niacin (S-N) or S-N plus antioxidants (S-N+A) compared with antioxidants alone or placebo. Angiographically documented stenosis regressed in the S-N group but progressed in all other groups. To assess the mechanism(s) responsible for these observations, surrogate markers of cholesterol absorption and synthesis were measured in a subset of 123 HATS participants at 24 months (on treatment) and at 38 months (off treatment). Treatment with S-N reduced desmosterol and lathosterol levels (cholesterol synthesis indicators) 46% and 36% ( P P r = 0.26, P r = −0.21, P These data suggest that changes in stenosis were attributable, in part, to changes in cholesterol metabolism.