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标题：Single session exercise stimulates formation of preβ1-HDL in leg muscle
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作者：Dmitri Sviridov ; Bronwyn Kingwell ; Anh Hoang 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2003
卷号：44
期号：3
页码：522-526
DOI：10.1194/jlr.M200436-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Physical activity can raise the level of circulating HDL cholesterol. Preβ₁-HDL is thought to be either the initial acceptor of cellular cholesterol or virtually the first particle in the pathway of the formation of HDL from apolipoprotein A-I and cellular lipids. We have therefore sought to identify preβ₁-HDL in arterial and venous circulations of exercising legs in healthy individuals and in subjects with stable Type 2 diabetes mellitus. Blood samples were taken simultaneously from the femoral artery and vein before and after 25 min cycling exercise. The major findings were, first, that exercise significantly increased plasma concentration of preβ₁-HDL (20% increase, P 1-HDL concentration was significantly higher in the venous compared with the arterial blood both before and after exercise in both diabetics and controls. In the combined population, formation of preβ₁-HDL at rest was 9.9 ± 5.2 mg/min and exercise enhanced preβ₁-HDL formation 6.6-fold in both groups.