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标题：A fish oil diet produces different degrees of suppression of apoB and triglyceride secretion in human apoB transgenic mouse strains
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作者：Carol Ko ; Shawn M. O'Rourke ; Li-Shin Huang 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2003
卷号：44
期号：10
页码：1946-1955
DOI：10.1194/jlr.M300172-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Human apolipoprotein B (apoB) transgenic (HuBTg) mouse strains were used to assess genetic effects on the response to fish oil (FO), a source of n-3 fatty acids. A congenic HuBTg strain of the C57BL/6 (B6) background and six F1 HuBTg strains were fed a FO for 2 weeks. Different responses of plasma lipid levels to FO were observed among these strains. In particular, plasma apoB levels changed minimally in FO-fed male B6 HuBTg mice, but increased markedly (∼40%) in FO-fed male FVB/NJ (FVB) × B6 F1 HuBTg mice. These strain differences were determined mainly by hepatic apoB secretion rates and were likely regulated by posttranscriptional mechanisms. In addition, plasma triglyceride (TG) levels were reduced (14%) in FO-fed B6 mice, but not in FVB × B6 mice. These strain differences were determined mainly by TG secretion rates, but were not due to differences in hepatic lipogenesis. Hepatic mRNA levels of acyl-CoA oxidase, reflective of peroxisomal β-oxidation rate, were increased in FO-fed B6 but not in FVB × B6 mice, which could account for the difference in TG secretion rates. In summary, differential effects of FO on plasma apoB and TG levels in B6 and FVB × B6 HuBTg mice were associated with strain differences in hepatic apoB and TG secretion and in peroxisomal β-oxidation.