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标题：Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men
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作者：Leon J. Schurgers ; Martin J. Shearer ; Berry A. M. Soute 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2002
卷号：43
期号：6
页码：878-884
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Little is known of how the fat components of diets influence the absorption and metabolism of vitamin K and the possible consequences to the synthesis of vitamin K-dependent (VKD) proteins in different target organs. We have evaluated the effects of two diets on circulating phylloquinone (K₁) and triacylglycerols (TAG). One diet was enriched with corn oil (CO) (also rich in γ-tocopherol) and the other with an olive/sunflower (O/SO) mixture (rich in α-tocopherol). Effects on γ-carboxylation were assessed from coagulation assays and sensitive assays for undercarboxylated prothrombin (ucFII) and osteocalcin (ucOC). Total plasma matrix Gla-protein (MGP) was also measured. After an initial adjustment diet, 26 healthy young men were fed, in a crossover design, the O/SO or CO diet for 2 weeks. Mean intakes of K₁ during consumption of adjustment, O/SO, and CO diets were 225 μg/day, 291 μg/day, and 291 μg/day, respectively. Mean fasting levels of TAG and K₁ were both significantly reduced by the CO diet, but not by the O/SO diet. Neither diet reduced FII activity but ucFII became detectable in nine subjects, eight of whom showed this abnormality with both diets. The CO diet induced a rise in ucOC ( P r = −0.71, P We conclude that both oils, notably CO, affected vitamin K absorption and/or metabolism which may increase the requirements for γ-carboxylation. The mechanism is unclear but may result from interactions of vitamin K with PUFA and/or other lipid components such as vitamin E.