文章基本信息

标题：ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan
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作者：Katherine Olin-Lewis ; Ronald M. Krauss ; Michael La Belle 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2002
卷号：43
期号：11
页码：1969-1977
DOI：10.1194/jlr.M200322-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Retention of apolipoprotein (apo)B and apoE-containing lipoproteins by extracellular vascular proteoglycans is critical in atherogenesis. Moreover, high circulating apoC-III levels are associated with increased atherosclerosis risk. To test whether apoC-III content of apoB-containing lipoproteins affects their ability to bind to the vascular proteoglycan biglycan, we evaluated the impact of apoC-III on the interaction of [³⁵S]SO₄-biglycan derived from cultured arterial smooth muscle cells with lipoproteins obtained from individuals across a spectrum of lipid concentrations. The extent of biglycan binding correlated positively with apoC-III levels within VLDL (r = 0.78, P P P ApoC-III content may thus be a marker for lipoproteins characterized as having an increased ability to bind proteoglycans.