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标题：Plasma kinetics of VLDL and HDL apoC-I in normolipidemic and hypertriglyceridemic subjects
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作者：Jeffrey S. Cohn ; Michel Tremblay ; Rami Batal 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2002
卷号：43
期号：10
页码：1680-1687
DOI：10.1194/jlr.M200055-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：ApoC-I has several different lipid-regulating functions including, inhibition of receptor-mediated uptake of plasma triglyceride-rich lipoproteins, inhibition of cholesteryl ester transfer activity, and mediation of tissue fatty acid uptake. Since little is known about the rate of production and catabolism of plasma apoC-I in humans, the present study was undertaken to determine the plasma kinetics of VLDL and HDL apoC-I using a primed constant (12 h) intravenous infusion of deuterium-labeled leucine. Data were obtained for 14 subjects: normolipidemics (NL, n = 4), hypertriglyceridemics (HTG, n = 4) and combined hyperlipidemics (CHL, n = 6). Plasma VLDL triglyceride (TG) levels were 0.59 ± 0.03, 4.32 ± 0.77 ( P P P P P P r = −0.63 and −0.62, respectively, P Our results demonstrate that increased levels of plasma and VLDL apoC-I in hypertriglyceridemic subjects (with or without elevated LDL-C levels) are associated with increased levels of plasma VLDL apoC-I production.