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标题：Cholecystectomy prevents expansion of the bile acid pool and inhibition of cholesterol 7α-hydroxylase in rabbits fed cholesterol
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作者：Guorong Xu ; Gerald Salen ; Benjamin L. Shneider 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2001
卷号：42
期号：9
页码：1438-1443
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：To study the effect of cholecystectomy on the regulation of classic and alternative bile acid syntheses, gallbladder-intact (n = 20) and cholecystectomized (n = 20) New Zealand White rabbits were fed either chow or chow with 2% cholesterol (3 g/day). After 10 days, bile fistulas were constructed in half of each rabbit group to recover and measure the bile acid pool and biliary bile acid flux. After cholesterol feeding, the bile acid pool size increased from 268 ± 55 to 444 ± 77 mg ( P P P P —Xu, G., G. Salen, B. L. Shneider, M. Ananthanarayanan, S. Shefer, L. Ma, A. Batta, L. B. Nguyen, J. J. Lingutla, G. S. Tint, M. Pcolinsky, and F. J. Suchy. Cholecystectomy prevents expansion of the bile acid pool and inhibition of cholesterol 7α-hydroxylase in rabbits fed cholesterol. J. Lipid Res. 2001. 42: 1438–1443.
关键词：apical sodium-dependent bile acid transporter ; sodium/taurocholate cotransporting polypeptide ; bile acid synthesis ; cholesterol 27-hydroxylase ; bile acid transport