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标题：Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes
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作者：H. Merzouk ; S. Madani ; A. Boualga 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2001
卷号：42
期号：7
页码：1152-1159
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipoprotein cholesterol contents were also examined. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, macrosomic pups had higher serum, LDL-HDL₁, and HDL_2-3 cholesterol levels ( P P —Merzouk, H., S. Madani, A. Boualga, J. Prost, M. Bouchenak, and J. Belleville. Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes. J. Lipid Res. 2001. 42: 1152–1159.
关键词：maternal diabetes ; macrosomia ; LCAT ; ACAT ; cholesterol 7α-hydroxylase ; HMG-CoA reductase