文章基本信息

标题：Effect of maternal hypercholesterolemia on fetal sterol metabolism in the Golden Syrian hamster
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作者：Julie A. McConihay ; Paul S. Horn ; Laura A. Woollett 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2001
卷号：42
期号：7
页码：1111-1119
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The fetus obtains a significant amount of cholesterol from de novo synthesis. Studies have suggested that maternal cholesterol may also contribute to the cholesterol accrued in the fetus. Thus, the present studies were completed to determine whether diet-induced maternal hypercholesterolemia would affect fetal sterol metabolism. To accomplish this, maternal plasma cholesterol concentrations were increased sequentially by feeding hamsters 0.0%, 0.12%, 0.5%, and 2.0% cholesterol. At 11 days into a gestational period of 15.5 days, cholesterol concentrations and sterol synthesis rates were measured in the three fetal tissues: the placenta, yolk sac, and fetus. In the placenta and yolk sac, the cholesterol concentration increased significantly when dams were fed as little as 0.12% cholesterol ( P P P —McConihay, J. A., P. S. Horn, and L. A. Woollett. Effect of maternal hypercholesterolemia on fetal sterol metabolism in the Golden Syrian hamster. J. Lipid Res. 2001. 42: 1111–1119.
关键词：fetus ; embryo ; placenta ; fetal membranes ; yolk sac ; cholesterol