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标题：Impact of hydrogenated fat on high density lipoprotein subfractions and metabolism
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作者：A. H. Lichtenstein ; M. Jauhiainen ; S. McGladdery 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2001
卷号：42
期号：4
页码：597-604
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Relative to saturated fatty acids, trans -fatty acids/hydrogenated fat-enriched diets have been reported to increase low density lipoprotein (LDL) cholesterol levels and either decrease or have no effect on high density lipoprotein (HDL) cholesterol levels. To better understand the effect of trans -fatty acids/hydrogenated fat on HDL cholesterol levels and metabolism, 36 subjects (female, n = 18; male, n = 18) were provided with each of three diets containing, as the major sources of fat, vegetable oil-based semiliquid margarine, traditional stick margarine, or butter for 35-day periods. LDL cholesterol levels were 155 ± 27, 168 ± 30, and 177 ± 32 mg/dl after subjects followed the semiliquid margarine, stick margarine, and butter-enriched diets, respectively. HDL cholesterol levels were 43 ± 10, 42 ± 9, and 45 ± 10 mg/dl, respectively. Dietary response in apolipoprotein (apo) A-I levels was similar to that in HDL cholesterol levels. HDL₂ cholesterol levels were 12 ± 7, 11 ± 6, and 14 ± 7 mg/dl, respectively. There was virtually no effect of dietary fat on HDL₃ cholesterol levels. The dietary perturbations had a larger effect on particles containing apoA-I only (Lp A-I) than apoA-I and A-II (Lp A-I/A-II). Cholesterol ester transfer protein (CETP) activity was 13.28 ± 5.76, 15.74 ± 5.41, and 14.35 ± 4.77 mmol × h⁻¹ × ml⁻¹, respectively. Differences in CETP, phospholipid transfer protein activity, or the fractional esterification rate of cholesterol in HDL did not account for the differences observed in HDL cholesterol levels. These data suggest that the saturated fatty acid component, rather than the trans - or polyunsaturated fatty acid component, of the diets was the putative factor in modulating HDL cholesterol response. —Lichtenstein, A. H., M. Jauhiainen, S. McGladdery, L. M. Ausman, S. M. Jalbert, M. Vilella-Bach, C. Ehnholm, J. Frohlich, and E. J. Schaefer. Impact of hydrogenated fat on high density lipoprotein subfractions and metabolism. J. Lipid Res. 2001. 42: 597–604.
关键词：low density lipoprotein ; apoA-I ; hydrogenated fat ; trans -fatty acids ; saturated fatty acids ; polyunsaturated fatty acids ; cholesterol ; cholesterol ester transfer protein ; phospholipid transfer protein ; fractional esterification rate of cholesterol ; diet ; butter ; margarine