文章基本信息

标题：Enhanced dietary fat clearance in postobese women
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作者：May Faraj ; Peter Jones ; Allan D. Sniderman 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2001
卷号：42
期号：4
页码：571-580
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The objective of this study was to examine the postprandial response to an exogenous fat source in eight weight-stable postobese subjects (2–3 years after gastric bypass) and eight matched control women, using a stable isotope, [¹³C]oleate. After a high fat breakfast meal (1,062 cal, 67% fat), [¹³C]oleate in triglyceride (TG)-rich lipoproteins (S_f >400 and S_f 20–400) and nonesterified fatty acids (NEFA), and ¹³C in breath CO₂, were monitored over 8 h. There were no differences in resting energy expenditure, thermic effect of food, carbohydrate/fat oxidation ratio, breath ¹³CO₂ enrichment, or fecal fat content between postobese and control subjects. Postprandially, there was no difference in S_f 20–400 TG or NEFA, but postobese subjects had lower S_f >400 incremental area under the curve (AUC) (−33%, P P 13C in S_f >400 TG returned to fasting levels 4 h earlier in postobese subjects and was lower than in control subjects at 4 and 6 h ( P 13C]NEFA profiles. In control subjects [¹³C]NEFA increased markedly over 8 h; postobese subject [¹³C]NEFA remained close to fasting nonenriched values, and was strikingly lower than in control subjects (72% lower by AUC, P P P —Faraj, M., P. Jones, A. D. Sniderman, and K. Cianflone. Enhanced dietary fat clearance in postobese women. J. Lipid Res. 2001. 42: 571–580.
关键词：triglyceride ; C3adesArg ; stable isotope ; [¹³C]oleate ; nonesterified fatty acid ; insulin ; leptin