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标题：Walnut-enriched diet increases the association of LDL from hypercholesterolemic men with human HepG2 cells
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作者：Sonia Muñoz ; Manuel Merlos ; Daniel Zambón 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2001
卷号：42
期号：12
页码：2069-2076
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：In a randomized, cross-over feeding trial involving 10 men with polygenic hypercholesterolemia, a control, Mediterranean-type cholesterol-lowering diet, and a diet of similar composition in which walnuts replaced ~35% of energy from unsaturated fat, were given for 6 weeks each. Compared with the control diet, the walnut diet reduced serum total and LDL cholesterol by 4.2% ( P = 0.176), and 6.0% ( P = 0.087), respectively. No changes were observed in HDL cholesterol, triglycerides, and apolipoprotein A-I levels or in the relative proportion of protein, triglycerides, phospholipids, and cholesteryl esters in LDL particles. The apolipoprotein B level declined in parallel with LDL cholesterol (6.0% reduction). Whole LDL, particularly the triglyceride fraction, was enriched in polyunsaturated fatty acids from walnuts (linoleic and α-linolenic acids). In comparison with LDL obtained during the control diet, LDL obtained during the walnut diet showed a 50% increase in association rates to the LDL receptor in human hepatoma HepG2 cells. LDL uptake by HepG2 cells was correlated with α-linolenic acid content of the triglyceride plus cholesteryl ester fractions of LDL particles ( r ² = 0.42, P —Muñoz, S., M. Merlos, D. Zambón, C. Rodríguez, J. Sabaté, E. Ros, and J. C. Laguna. Walnut-enriched diet increases the association of LDL from hypercholesterolemic men with human HepG2 cells. J. Lipid Res. 2001. 42: 2069–2076.
关键词：fatty acids ; LDL receptor ; polygenic hypercholesterolemia