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标题：Hydrogenated fat consumption affects acylation-stimulating protein levels and cholesterol esterification rates in moderately hypercholesterolemic women
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作者：Nirupa R. Matthan ; Katherine Cianflone ; Alice H. Lichtenstein 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2001
卷号：42
期号：11
页码：1841-1848
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：To determine whether hydrogenated fat consumption alters triglyceride metabolism and cholesterol esterification rates, 14 women (65–71 years of age) were provided with each of four diets for 5-week periods according to a randomized cross-over design. The experimental diets contained either soybean oil (SO), low trans squeeze (SQM), medium trans tub (TM), or high trans stick (SM) margarines. Triglyceride uptake by adipose tissue was determined by measuring plasma acylation-stimulating protein (ASP), FFA, glucose, and insulin levels, while rates of transfer and esterification rate of newly synthesized cholesterol (ER) were derived by using plasma CETP levels and the deuterium incorporation methodology. Plasma ASP levels were lowest ( P P P −1) diet and highest after consumption of the SQM (0.216 ± 0.123 g·day⁻¹) diet. In addition, ASP levels were negatively correlated with FFA ( r = −0.63, P r = −0.56, P r = −0.41, P r = 0.58 and 0.47, for VLDL and LDL cholesterol, P r = −0.51, P 2 subfraction ( r = 0.53 and 0.45, respectively, P —Matthan, N. R., K. Cianflone, A. H. Lichtenstein, L. M. Ausman, M. Jauhiainen, and P. J. H. Jones. Hydrogenated fat consumption affects acylation-stimulating protein levels and cholesterol esterification rates in moderately hypercholesterolemic women. J. Lipid Res. 2001. 42: 1841–1848.
关键词：CETP ; dietary fat ; HDL cholesterol ; hydrogenation ; LDL cholesterol ; trans fatty acids ; triglyceride metabolism