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标题：Acute and chronic effects of a 24-hour intravenous triglyceride emulsion challenge on plasma lecithin: cholesterol acyltransferase, phospholipid transfer protein, and cholesteryl ester transfer protein activities
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作者：S. C. Riemens ; A. Van Tol ; W. J. Sluiter 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1999
卷号：40
期号：8
页码：1459-1466
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Lecithin:cholesterol acyltransferase (LCAT), phospholipid transfer protein (PLTP), and cholesteryl ester transfer protein (CETP) are key factors in remodeling of high density lipoproteins (HDL) and triglyceride-rich lipoproteins. We examined the effect of a large, 24 h intravenous fat load on plasma lipids and free fatty acids (FFA) as well as on plasma LCAT, PLTP, and CETP activity levels in 8 healthy men. The effect of concomitant insulin infusion was also studied, with 1 week between the study days. During Lipofundin^R infusion, plasma triglycerides and FFA strongly increased after 8 and 24 h ( P P P P P P P P P = 0.05) were increased, whereas HDL cholesterol was decreased ( P P P In summary, plasma LCAT, PLTP, and CETP activity levels are stimulated by a large intravenous fat load, but the time course of their responses and the effects of insulin coadministration are different. Changes in plasma LCAT and PLTP activities may be implicated in HDL and triglyceride-rich lipoprotein remodeling under the present experimental conditions. —Riemens, S. C., A. Van Tol, W. J. Sluiter, and R. P. F. Dullaart. Acute and chronic effects of a 24-hour intravenous triglyceride emulsion challenge on plasma lecithin:cholesterol acyltransferase, phospholipid transfer protein, and cholesteryl ester transfer protein activities. J. Lipid Res. 1999. 40: 1459–1466.
关键词：CETP ; PLTP ; LCAT ; triglyceride emulsion ; insulin