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标题：Chylomicron metabolism in an animal model for hyperlipoproteinemia type I
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作者：Roger Savonen ; Knut Nordstoga ; Björn Christophersen 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1999
卷号：40
期号：7
页码：1336-1346
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Mink homozygous for the mutation Pro214Leu in lipoprotein lipase (LPL) had only traces of LPL activity but amounts of LPL protein in their tissues similar to those of normal mink. In normal mink, lymph chylomicrons from rats given [³H]retinol (incorporated into retinyl esters, providing a core label) and [¹⁴C]oleic acid (incorporated mainly in triglycerides (TG)) were rapidly cleared from the circulation. In the homozygous mink, clearance was much retarded. The ratio of TG to core label in plasma did not decrease and much less [¹⁴C]oleic acid appeared in plasma. Still, half of the labeled material disappeared from the circulating blood within 30–40 min and the calculated total turnover of TG in the hypertriglyceridemic mink was almost as large as in normal mink. The core label was distributed to the same tissues in hypertriglyceridemic mink as in normal mink. Half to two-thirds of the cleared core label was in the liver. The large difference was that in the hypertriglyceridemic mink, TG label (about 40% of the total amount removed) followed the core label to the liver and there was no preferential uptake of TG over core label in adipose or muscle tissue. In normal mink, only small amounts of TG label ( —Savonen, R., K. Nordstoga, B. Christophersen, A. Lindberg, Y. Shen, M. Hultin, T. Olivercrona, and G. Olivecrona. Chylomicron metabolism in an animal model for hyperlipoproteinemia type I. J. Lipid Res. 1999. 40: 1336–1346.
关键词：remnants ; retinyl esters ; triglycerides ; fatty acids ; apolipoprotein B