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标题：Cell cholesterol efflux: integration of old and new observations provides new insights
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作者：George H. Rothblat ; Margarita de la Llera-Moya ; Veronique Atger 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1999
卷号：40
期号：5
页码：781-796
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Numerous studies using a variety of cell/acceptor combinations have demonstrated differences in cholesterol efflux among cells. These studies also show that different acceptors, ranging from simple molecules like cyclodextrins to serum, stimulate efflux through a variety of mechanisms. By combining early observations with data derived from recent studies, it is now possible to formulate a model for cell cholesterol efflux which proposes that an array of different mechanisms, including aqueous diffusion, lipid-free apolipoprotein membrane microsolubilization, and SR-BI-mediated cholesterol exchange contribute to cholesterol flux. In this model the relative importance of each mechanism would be determined both by the cell type and the nature of the extracellular cholesterol acceptor. —Rothblat, G. H., M. de la Llera-Moya, V. Atger, G. Kellner-Weibel, D. L. Williams, and M. C. Phillips. Cell cholesterol efflux: integration of old and new observations provides new insights. J. Lipid Res. 1999. 40: 781–796.
关键词：tissue culture cells ; cholesterol ; efflux ; influx ; high density lipoprotein ; lipoproteins ; phospholipid ; plasma membrane ; cyclodextrin ; scavenger receptor class B, type I ; review