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标题：Characterization of remnant-like particles isolated by immunoaffinity gel from the plasma of type III and type IV hyperlipoproteinemic patients
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作者：Caroline Marcoux ; Michel Tremblay ; Katsuyuki Nakajima 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1999
卷号：40
期号：4
页码：636-647
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Previous studies have investigated the potential atherogenicity and thrombogenicity of triglyceride-rich lipoprotein (TRL) remnants by isolating them from plasma within a remnant-like particle (RLP) fraction, using an immunoaffinity gel containing specific anti-apoB-100 and anti-apoA-I antibodies. In order to characterize lipoproteins in this RLP fraction and to determine to what extent their composition varies from one individual to another, we have used automated gel filtration chromatography to determine the size heterogeneity of RLP isolated from normolipidemic control subjects (n = 8), and from type III (n = 6) and type IV (n = 9) hyperlipoproteinemic patients, who by selection had similarly elevated levels of plasma triglyceride (406 ± 43 and 397 ± 35 mg/dl, respectively). Plasma RLP triglyceride, cholesterol, apoB, apoC-III, and apoE concentrations were elevated 2- to 6-fold ( P 1 ) RLP are heterogeneous in size and composition in both normolipidemic and hypertriglyceridemic subjects, and 2 ) the apoE and apoC-III composition of RLP is different in type III compared to type IV hyperlipoproteinemic patients. —Marcoux, C., M. Tremblay, K. Nakajima, J. Davignon, and J. S. Cohn. Characterization of remnant-like particles isolated by immunoaffinity gel from the plasma of type III and type IV hyperlipoproteinemic patients. J. Lipid Res. 1999. 40: 636–647.
关键词：triglyceride-rich lipoprotein remnants ; apoC-III ; apoE ; LDL ; atherosclerosis