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标题：Fractional oxidation of chylomicron-derived oleate is greater than that of palmitate in healthy adults fed frequent small meals
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作者：Dorothy E. Schmidt ; John B. Allred ; C. Lawrence Kien 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1999
卷号：40
期号：12
页码：2322-2332
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Differences in oxidation of individual dietary fatty acids could contribute to the effect of dietary fat composition on risk factors for non-insulin-dependent diabetes mellitus and cardiovascular disease. Using a novel stable isotope technique, we compared fractional oxidation of chylomicron-derived oleate and palmitate in 10 healthy adults in a crossover study. 1-¹³C-labeled oleate or palmitate was emulsified into a eucaloric formula diet administered each 20 min for 7 h to produce a plateau in excretion of ¹³C label in breath CO₂. Unlabeled oleate and palmitate each provided 16% of dietary energy, and other fatty acids provided 8% of energy. Total dietary fat was 40% of energy, carbohydrate was 46%, and protein was 14%. Diet without tracer was fed for 2 h before beginning tracer administration to establish a baseline fed state. Relative oxidation of oleate versus palmitate was defined as fractional oxidation of oleate divided by fractional oxidation of palmitate. Relative oxidation averaged 1.21 (99.5% confidence interval = 1.03–1.39), indicating that fractional oxidation of oleate was significantly greater than that of palmitate.— Schmidt, D. E., J. B. Allred, and C. L. Kien. Fractional oxidation of chylomicron-derived oleate is greater than that of palmitate in healthy adults fed frequent small meals. J. Lipid Res. 1999. 40: 2322–2332.
关键词：dietary fat ; chylomicrons ; fatty acid oxidation ; stable isotopes