文章基本信息

标题：Metabolism of coprostanol-C14 and cholestanol-4-C14 in man
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作者：R. S. Rosenfeld ; Barnett Zumoff ; Leon Hellman 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1963
卷号：4
期号：3
页码：337-340
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Coprostanol-C¹⁴, biosynthetically prepared, was administered orally to two patients, and cholestanol-4-C¹⁴ was administered to one of them 10 months later. At the time when radioactivity in the circulation was at a maximum, 3.6 and 3.5% of the administered labeled coprostanol was present in the plasma; the corresponding value after administration of cholestanol-C¹⁴ was 4.7%. The dynamic behavior of absorbed radioactive cholestanol was identical with that of orally ingested cholesterol-4-C¹⁴, including the esterification process; on the other hand, virtually no coprostanol ester was present in the circulation. It is suggested that the conformation of the A/B rings or configuration at C-3 are related to the esterification mechanism of sterols. After 5 days, over 50% of both compounds had been excreted in the feces. The conversion of coprostanol-C¹⁴ to coprostanone-C¹⁴ has been demonstrated.