文章基本信息

标题：Three polymorphisms associated with low hepatic lipase activity are common in African Americans
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作者：Liangcai Nie ; Sijing Niu ; Gloria Lena Vega 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1998
卷号：39
期号：9
页码：1900-1903
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：We have shown previously that a hepatic lipase allele (designated –514T) is common among African Americans and contributes to low hepatic lipase activity in this population. To identify other hepatic lipase alleles associated with low hepatic lipase activity in this population, the coding region and intron–exon boundaries of the hepatic lipase gene were sequenced in 20 African American men with low hepatic lipase activity. Two polymorphisms (N193S and L334F) were associated with low post-heparin plasma hepatic lipase activity and were much more common in African Americans than in whites. This finding, together with our previous data on the –514T allele, indicates that at least three different hepatic lipase polymorphisms associated with low hepatic lipase activity are common among African Americans. Analysis of hepatic lipase haplotypes revealed that 97% of African Americans have at least one hepatic lipase allele that is associated with low hepatic lipase activity.— Nie, L., S. Niu, G. L. Vega, L. T. Clark, A. Tang, S. M. Grundy, and J. C. Cohen. Three polymorphisms associated with low hepatic lipase activity are common in African Americans. J. Lipid Res. 1998. 39: 1900–1903.
关键词：-514 allele ; HDL-cholesterol