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标题：Marked reduction in bile acid synthesis in cholesterol 7α-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia
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作者：Margrit Schwarz ; David W. Russell ; John M. Dietschy 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1998
卷号：39
期号：9
页码：1833-1843
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：These studies used mice that were deficient in cholesterol 7α-hydroxylase to determine the effects of reduced bile acid synthesis on cholesterol homeostasis. In mice lacking this enzyme, bile acid synthesis was reduced from 8.3 to 3.4 μmol/day per 100 g body weight, the intestinal bile acid pool was decreased from 62.5 to 13.2 μmol/100 g bw, and the proportion of hyodeoxycholate, relative to cholate, in this pool was significantly increased. Associated with these changes, intestinal cholesterol absorption decreased from 37% to This study demonstrates the complex interactions between bile acid and cholesterol metabolism and the dramatic effects of eliminating a single gene product; however, even though a major catabolic pathway was deleted, cholesterol balance across the animal was maintained.— Schwarz, M., D. W. Russell, J. M. Dietschy, and S. D. Turley. Marked reduction in bile acid synthesis in cholesterol 7α-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia. J. Lipid Res. 1998. 39: 1833–1843.
关键词：cholesterol 7α-hydroxylase ; cholesterol absorption ; cholesterol synthesis ; bile acid pool size ; liver ; small intestine