文章基本信息

标题：Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice
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作者：Sonja Ehnholm ; Ko Willems van Dijk ; Belinda van't Hof 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1998
卷号：39
期号：6
页码：1248-1253
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：To study the function of plasma phospholipid transfer protein (PLTP) in vivo, a liver directed adenoviral gene transfer system was used to overexpress human PLTP in mice. For the experiments, two strains of mice, wild type (C57/Bl) and mice transgenic for the human apoA-I gene (HuApoA-ITg), were utilized. Five days after injection of the recombinant PLTP adenovirus, wild type mice showed a 4-fold increase in serum PLTP activity in (12.2 ± 1.3 μmol/ml/per h to 48.1 ± 8.6 μmol/ml per h (+394%), P P P P The results demonstrate that plasma phospholipid transfer protein in vivo causes high density lipoprotein (HDL) conversion and thereby plays a central role in HDL metabolism.—Ehnholm, S., K. Willems van Dijk, B. van't Hof, A. van der Zee, V. M. Olkkonen, M. Jauhiainen, M. Hofker, L. Havekes, and C. Ehnholm. Adenovirus-mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice. J. Lipid Res. 1998. 39: 1248–1253.
关键词：recombinant adenovirus ; phospholipid transfer protein ; HDL metabolism ; HDL conversion ; apolipoprotein A-I ; lipid metabolism