文章基本信息

标题：Genetically modified mice for the study of apolipoprotein B
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作者：Edward Kim ; Stephen G. Young
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1998
卷号：39
期号：4
页码：703-723
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Over the past five years, several laboratories have used a variety of transgenic and gene-targeted mice to study apoB. These studies have helped in 1 ) generating new mouse models suitable for investigating the genetic and environmental factors affecting atherogenesis; 2 ) providing systems for investigating apoB structure/function relationships; 3 ) understanding the regulation of apoB gene expression in the intestine; 4 ) delineating a critical role for apoB expression in mouse embryonic development; 5 ) yielding insights into the “physiologic rationale” for the existence of the two different forms of apoB, apoB-48 and apoB-100, in mammalian metabolism; and 6 ) providing basic insights into mechanisms involved in the human apoB deficiency syndrome, familial hypobetalipoproteinemia. —Kim, E., and S. G. Young. Genetically modified mice for the study of apolipoprotein B. J. Lipid Res. 1998. 39: 703–723.
关键词：apolipoprotein B ; lipids ; cholesterol ; triglycerides ; atherosclerosis ; mouse ; transgenic ; gene targeting ; knockout