文章基本信息

标题：Fatty acid transport: difficult or easy?
本地全文：下载
作者：James A. Hamilton
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1998
卷号：39
期号：3
页码：467-481
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Transport of unesterified fatty acids (FA) into cells has been viewed either as a simple diffusion process regulated mainly by lipid physical chemistry or as a more complex process involving protein catalysis. In this review FA transport in cell membranes is broken down into three essential steps: adsorption, transmembrane movement, and desorption. The physical properties of FA in aqueous, membrane, and protein environments relevant to transport mechanisms are discussed, with emphasis on recent information derived from NMR and fluorescence studies. Because of their low solubility in water and high hydrophobicity, FA bind rapidly and avidly to model membranes (phospholipid bilayers); if albumin is a donor, FA desorb rapidly to reach their equilibrium distribution between the membrane and albumin. The ionization properties of FA in a phospholipid bilayer result in a high population of the un-ionized form (∼50%) at pH 7.4, which diffuses across the lipid bilayer (flip-flops) rapidly (t_1/2 Hamilton, J. A. Fatty acid transport: difficult or easy? J. Lipid Res. 1998. 39: 467–481.
关键词：albumin ; diffusion ; fluorescence ; intracellular pH ; phospholipid bilayer ; membrane ; NMR ; transbilayer movement ; uncoupling protein ; vesicles