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标题：Preferential clearance of apoB-48-containing lipoproteins after heparin-induced lipolysis is modulated by lipoprotein lipase activity
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作者：André P. van Beek ; Harrold H. J. J. van Barlingen ; Florianne C. de Ruijter-Heijstek 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1998
卷号：39
期号：2
页码：322-332
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The acute effects of intravenous heparin administration (50 U/kg body weight) on apolipoprotein (apo)B-48 and apoB-100-containing lipoproteins in relation to postheparin lipase activities were studied in ten healthy normolipidemic volunteers. Five subjects returned to receive sham injections with saline. Lipoproteins were separated from plasma by density gradient ultracentrifugation at baseline, 3, and 20 min postheparin. ApoB-48 and apoB-100 in d r = 0.81, P = 0.004) and apoB-100 ( r = 0.91, P 140 mU/mL), comparable percentual reductions for apoB-48 and apoB-100 were seen. Pharmacokinetic analysis revealed first-order kinetics for the clearance of apoB-48 in d van Beek, A. P., H. H. J. J. van Barlingen, F. C. de Ruijter-Heijstek, H. Jansen, D. W. Erkelens, G. M. Dallinga-Thie, and T. W. A. de Bruin. Preferential clearance of apoB-48-containing lipoproteins after heparin-induced lipolysis is modulated by lipoprotein lipase activity. J. Lipid Res. 1998. 39: 322–332.
关键词：chylomicron ; apoB-100 ; triglyceride-rich lipoproteins ; hepatic lipase ; chylomicron-remnant clearance ; pharmacokinetics