文章基本信息

标题：Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals
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作者：Reinald Pamplona ; Manuel Portero-Otín ; David Riba 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1998
卷号：39
期号：10
页码：1989-1994
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. Accordingly, the fatty acids analyses of liver mitochondria from eight mammals, ranging in maximum life span from 3.5 to 46 years, show that the total number of double bonds and the peroxidizability index are negatively correlated with maximum life span ( r = −0. 88, P r = −0.87, P r = −0.89, P r = 0.97, P 6-desaturase activity in longevous animals ( r = −0.96, P —Pamplona, R., M. Portero-Otín, D. Riba, C. Ruiz, J. Prat, M. J. Bellmunt, and G. Barja. Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. J. Lipid Res. 1998. 39: 1989–1994.
关键词：diet ; docosahexaenoic acid ; double bond index ; fatty acids ; linolenic acid ; liver ; longevity ; oxidative stress ; polyunsaturated fatty acids ; n–3 ; n–6 ; unsaturation