文章基本信息

标题：Cell density can affect cholesteryl ester accumulation in the human THP-1 macrophage.
本地全文：下载
作者：A Rodriguez ; S D Kafonek ; A Georgopoulos 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1994
卷号：35
期号：11
页码：1909-1917
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Esterified cholesterol (EC) accumulation was induced in THP-1 macrophages after exposure to acetylated LDL (acLDL), and the extent of accumulation was dependent on cell density. EC mass was 5-fold greater in cells plated at 1.0 x 10(6) cells/35 mm dish compared to cells plated at density 4.0 x 10(6) cells/dish. In addition, [14C]oleate incorporation into EC also increased with decreasing cell number, with 4-fold greater incorporation (6 h: 177 +/- 0.014 vs. 45 +/- 0.001 pmol/mg cell protein, P