文章基本信息

标题：The economy of the enterohepatic circulation of bile acids in the baboon. 1. Studies of controlled enterohepatic circulation of bile acids.
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作者：R N Redinger ; J W Hawkins ; D M Grace 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1984
卷号：25
期号：5
页码：428-436
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：A primate model with controlled enterohepatic circulation has been developed which allowed short-term evaluation of bile salt pool size, cycling frequency, and fecal losses. We found that when bile salt secretion into the small bowel was increased above 700 mumol/hr bile acid pool cycling frequency was also increased. The latter allowed short-term regulation of bile salt pool size by affecting increased fecal losses. These compensatory mechanisms were associated with a return of bile acid secretion and cycling frequency to normal usually within 12-24 hours. Conversely, during decreased bile salt secretion, regulation of bile salt pool size was accomplished by decreased pool cycling, which decreased fecal losses. Bile acid secretion into the intestine was therefore a major determinant of bile salt cycling frequency. The latter affected bile salt fecal loss to provide short-term regulation of bile salt pool when feedback regulation of bile salt synthesis was nonoperative.