文章基本信息

标题：Synthesis of cyclopentano-N-methylphosphatidylethanolamines: aminolysis during the use of methylamine.
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作者：H Pajouhesh ; A J Hancock
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1984
卷号：25
期号：3
页码：310-312
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Monomethylamine and N-benzyl-N-methylamine were used as nucleophiles in the amination of the bromoethylester of cyclopentano-phosphatidic acid. The former reagent led to extensive aminolysis and the quantitative formation of N-methylpalmitamide, rather than the desired cyclopentano-phosphatidyl-N-methylethanolamine. However, the method of Shapiro and Rabinsohn (1964. Biochemistry. 3:603-605), in which N-benzyl-N-methylamine was used as a nucleophile, was adapted for a successful synthesis.