文章基本信息

标题：Biochemistry of the sphingolipids: XII. conversion of cerebrosides to ceramides and sphingosine; structure of Gaucher cerebroside
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作者：H. E. Carter ; J. A. Rothfus ; Roy Gigg 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1961
卷号：2
期号：3
页码：228-234
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：An improved procedure for the conversion of cerebroside to ceramide and sphingosine has been devised, consisting of periodate opening of the glycosidic ring, reduction with NaBH₄, and hydrolysis under very mild acid conditions to ceramide. The over-all yield is excellent and only the erythro isomer results. Alkaline hydrolysis of ceramide gives erythro-sphingosine in good yield. Application of this procedure to Gaucher cerebroside has shown it to contain the “normal” erythro-sphingosine.