文章基本信息

标题：Studies of trans-3-methyl-2-hexenoic acid in normal and schizophrenic humans
本地全文：下载
作者：Stuart G. Gordon ; Kathleen Smith ; Joseph L. Rabinowitz 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1973
卷号：14
期号：4
页码：495-503
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The report that sweat of certain schizophrenics contains the branched chain fatty acid, trans -3-methyl-2-hexenoic acid (TMHA), stimulated an investigation to evaluate the relationship between this fatty acid and schizophrenia. A sensitive and specific gas–liquid chromatography–mass spectroscopic procedure was developed for analyzing biological fluids for TMHA. Analysis of sweat samples from normal and schizophrenic subjects indicated that the sweat of both groups contains comparable quantities of this fatty acid. In addition, the fate of intravenously administered ¹⁴C-labeled TMHA was shown to be similar in normal and schizophrenic subjects. It is concluded that there is no relationship between TMHA and schizophrenia.
关键词：short-chain fatty acids ; gas–liquid chromatography–mass spectroscopy