文章基本信息

标题：Synthesis of sulfate esters of phosphatidylglycerol (diphytanyl ether analog)
本地全文：下载
作者：A. J. Hancock ; M. Kates
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1973
卷号：14
期号：4
页码：430-437
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Synthesis of 1- sn -phosphatidyl-3′- sn -glycero-1′-sulfate (phosphatidylglycero-1-sulfate) was achieved by monosulfation of 1- sn -phosphatidyl-3′- sn -glycerol (diphytanyl ether analog) with an equimolar amount of SO₃–pyridine complex at room temperature; with excess sulfation reagent at 60°C, the 1′,2′-disulfate ester was obtained. The phosphatidylglycero-2-sulfate isomer was synthesized by an unambiguous route starting from the bacterial 2,3-di- O -phytanyl- sn -glycerol. The synthetic phosphatidylglycerosulfates were characterized by analytical, chromatographic, optical rotatory, and spectral (infrared and NMR) data and compared with the phosphatidylglycerosulfate isolated from Halobacterium cutirubrum .
关键词：phosphosulfolipid ; halophilic bacteria ; 1- sn -phosphatidyl-3′- sn -glycero-1′-sulfate ; 1- sn -phosphatidyl-1′- sn -glycero-2′-sulfate ; 1- sn -phosphatidyl-3′- sn -glycero-1′,2′-disulfate ; 2- O -myristoyl-3- O -benzyl- sn -glycerol ; sulfation of phosphatidylglycerol ; 3′- O -benzyl phosphatidylglycerol ; NMR spectra ; infrared spectra ; optical rotations ; thin-layer chromatography