文章基本信息

标题：Hyperlipoproteinemia in fasting ponies
本地全文：下载
作者：M. D. Morris ; D. B. Zilversmit ; H. F. Hintz 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1972
卷号：13
期号：3
页码：383-389
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Ponies fasted for up to 8 days showed, both by agarose electrophoresis and preparative ultracentrifugation, the appearance of a pre-β-migrating, very low density lipoprotein fraction in plasma. This lipoprotein differs from the very low density lipoprotein found in humans and rats in that it contains a relatively smaller amount of total cholesterol, 85% of which is present in the unesterified form. By the 8th day of fasting, plasma triglyceride concentrations had increased from a prefasting level of 20 mg/dl to as high as 1000 mg/dl. The increase in plasma lipid concentrations as a result of fasting was highly variable. Accumulation of plasma cholesterol and triglyceride after injection of Triton WR 1339 was not related to the degree of fasting hyperlipidemia. This suggests that the hyperlipoproteinemia of fasting may result from an impaired utilization of very low density lipoproteins.
关键词：agarose electrophoresis ; β-lipoproteins ; pre-β-lipoproteins ; α-lipoproteins ; very low density lipoproteins ; high density lipoproteins ; free fatty acids ; cholesterol ; cholesteryl ester ; triglyceride ; phospholipid ; Triton WR 1339