文章基本信息

标题：Stimulation of cholesterol 7α-hydroxylase by phenobarbital in two strains of rats
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作者：S. Shefer ; S. Hauser ; E. H. Mosbach 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1972
卷号：13
期号：1
页码：69-70
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The effect of phenobarbital administration on the in vitro activity of cholesterol 7α-hydroxylase was investigated in two strains of rats. In rats of the Wistar strain the daily injection of phenobarbital (100 mg/kg per day ip for 5 days) produced a 33% increase in hepatic microsomal protein and a sixfold stimulation of specific activity of the enzyme. In rats of the Charles River colony (Sprague-Dawley derived) identical treatment with phenobarbital resulted in a 45% increase in hepatic microsomal protein and no change in the specific activity of cholesterol 7α-hydroxylase. Plasma phenobarbital concentrations were three to four times greater in the Wistar rats, suggesting that these strains differ also in their capacity to metabolize phenobarbital.
关键词：microsomal enzyme