文章基本信息

标题：Esterification of injected epicoprostanol in a human subject
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作者：R. S. Rosenfeld ; Leon Hellman
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1969
卷号：10
期号：2
页码：175-178
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：That a necessary requirement for in vivo esterification of 3-hydroxy sterols is the equatorial conformation of the hydroxyl group has been substantiated by the administration of epicoprostanol-3β-³H (3-OH equatorial) to a man with a complete biliary fistula. Radioactive epicoprostanol was identified in both free and esterified sterols of plasma. The specific activity of biliary sterols was much higher than that of plasma sterols; this indicated a preferential removal of epicoprostanol from circulating sterols. The appearance of tritium in body water demonstrated that a portion of the labeled epicoprostanol underwent oxidation at C-3.
关键词：5β-cholestan-3α-ol ; metabolism ; equatorial configuration