文章基本信息

标题：The use of computers to study rates of lipid metabolism
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作者：Nome Baker
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1969
卷号：10
期号：1
页码：1-24
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Many complex problems of lipid metabolism are especially suited for multicompartmental analysis with computers. Examples are presented. The use of a model as a means of communicating one's working hypothesis and the model as it relates to experimental design are discussed. A number of principles relating to experimental design and to the interpretation and presentation of data are illustrated by 12 studies selected from the literature. These include evaluations of turnover and transport rates of liver and plasma triglycerides, triglyceride synthesis, phospholipid synthesis, and lipid oxidation to CO₂. A discussion of computer-oriented vs. noncomputer-oriented techniques is included. Some of the practical problems involved in computer analysis are also considered. Among these are the choice of computer, computer applications, stepwise vs. multicompartmental analysis, validity of single-injection type experiments, avoidance of multicompartmental analysis, nonsteady state systems, and nomenclature.
关键词：models ; multicompartmental analysis ; free fatty acids ; triglycerides ; phospholipids ; carbon dioxide ; oxidation ; turnover rates ; transport ; irreversible disposal