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标题：Studies on the distribution of tocopherol in human serum lipoproteins
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作者：Eugene C. McCormick ; David G. Cornwell ; J. B. Brown 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：1960
卷号：1
期号：3
页码：221-228
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The tocopherol content of human serum proteins, isolated by density gradient and homogeneous density procedures, was determined by the Emmerie-Engel and phosphomolybdic acid methods. Serum tocopherol is found primarily in the lipoproteins. The low density lipoproteins, principally the S_f 3-9 lipoproteins, contain a major part of the total serum tocopherol, while high density lipoproteins contain the remainder. Serum tocopherol increases after oral administration and remains elevated for 24 hours. The increment in serum tocopherol from newly absorbed tocopherol is found first in the chylomicron and S_f 10-400 lipoprotein fractions. A tocopherol peak occurs in these fractions 4 hours after oral administration. This peak is followed by an increment in the tocopherol content of the S_f 3-9 and high density lipoprotein fractions which reaches a maximum plateau in from 8 to 10 hours and remains elevated from 14 to 16 hours. The distribution of newly absorbed tocopherol is discussed in relation to lipid absorption and transport of other lipids by the serum lipoproteins.