文章基本信息

标题：Role of Oxygen Radicals in the Pathogenesis of Gastric Mucosal Lesions Induced by Water-Immersion Restraint Stress and Burn Stress in Rats
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作者：Toshikazu YOSHIKAWA ; Norimasa YOSHIDA ; Yuji NAITO 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1990
卷号：8
期号：3
页码：227-234
DOI：10.3164/jcbn.8.227
出版社：The Society for Free Radical Research Japan
摘要：The formation of gastric mucosal lesions and the increase in thiobarbituric acid (TBA)-reactive substances induced by water-immersion restraint stress or burn stress in rats were significantly inhibited by the treatment with superoxide dismutase (SOD) and/or catalase. Allopurinol inhibited the formation of gastric mucosal injury induced by burn stress, but not the increase in TBA reactants. A drop in the polymorphonuclear leukocyte (PMN) count induced by an injection of anti-rat PMN antibody did not inhibit the aggravation of gastric mucosal lesions or the increase in TBA reactants in either of the stress models. These results suggest that active oxygen species and lipid peroxidation may play a role in the formation of gastric mucosal damage induced by stress. Reduced microcirculation of the gastric mucosa induced by water-immersion restraint or burn stress did not change following treatment with SOD and/or catalase, suggesting that the effectiveness of SOD and catalase on the gastric mucosal lesions induced by stress may occur via the scavenging of oxygen radicals, and not through an effect on gastric mucosal microcirculation.
关键词：oxygen radicals;lipid peroxidation;stress ulcer;superoxide dismutase;catalase