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标题：Effects of Doses and Duration of Iron Supplement on Iron Deficiency in Rats
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作者：Agnès DHUR ; Pilar GALAN ; Serge HERCBERG 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1989
卷号：7
期号：3
页码：193-200
DOI：10.3164/jcbn.7.193
出版社：The Society for Free Radical Research Japan
摘要：The effects of 3 doses and 2 durations of iron supplement on iron-deficient rats were investigated. Two groups of 15 rats were given, respectively, a low iron-containing diet (4-5mg Fe/kg diet) and a medium iron-containing diet (15mg Fe/kg diet) for 4 weeks. At that time the first group was anemic and the second group was moderately iron-deficient, as shown by their iron status parameters. The two groups were then each divided into 3 subgroups of 5 rats each that received the low iron-containing diet supplemented with 35, 150, or 250mg of iron in the ferrous sulfate form per kg diet. Changes in their iron status and mean body weight was followed after 8 and 14 days of supplementation. Results showed that, after 14 days of supplementation, a dose of 35ppm was not sufficient to normalize hematological parameters. However, doses of 150 and 250mg Fe/kg diet normalized all hematological parameters after 8 days of diet, and corrected the decrease in body weight gain.
关键词：iron deficiency;iron supplementation;rats;sulfate iron