文章基本信息

标题：Effect of Adriamycin Entrapped in Liposomes on Ovarian Carcinoma Cells
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作者：Naoki UENO ; Hiromitsu YABUSHITA ; Masayoshi NOGUCHI 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1989
卷号：7
期号：1
页码：53-58
DOI：10.3164/jcbn.7.53
出版社：The Society for Free Radical Research Japan
摘要：Adriamycin entrapped in small unilamellar vesicles (SUV-ADM) and that in multilamellar vesicles (MLV-ADM), composed of egg yolk phosphatidylcholine, cholesterol, and sulfatide in a molar ratio of 5:4:1, were examined for their effects on ovarian carcinoma AMOC-1 cells in comparison with free adriamycin. Cellular uptake and cytotoxicity were demonstrated for both SUV-ADM and MLV-ADM. The degrees of cellular uptake and cytotoxicity of SUV-ADM were comparable with those of free adriamycin, though those of MLV-ADM were somewhat lower than those of the free or SUV-entrapped drug. From these results and previous data obtained by pharmacokinetic study, the liposomes with the above composition are considered to be useful drug carriers for chemotherapy of ovarian tumors.
关键词：adriamycin;liposomes;ovarian carcinoma