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标题：Serum Levels of Tocopherol and Their Relationship to Risk Factor of Coronary Heart Disease in University Students
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作者：Kazuko HIRAI ; Rie HIGUCHI ; Masako AZUMA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1989
卷号：7
期号：1
页码：15-25
DOI：10.3164/jcbn.7.15
出版社：The Society for Free Radical Research Japan
摘要：This study assessed the biochemical status of serum α-tocopherol (Toc) and lipid in university students (60 males and 51 females) and searched for risk factors of coronary heart disease (CHD). No significant differences were observed between the sexes in total cholesterol (T-C) (170 and 181mg/100ml for males and females, respectively), low density lipoprotein-cholesterol (LDL-C) (116 and 118mg/100ml), and phospholipids (PL) (193 and 199mg/100ml). The levels of high density lipoprotein-cholesterol (HDL-C) were lower in males (54mg/100ml) than in females (62mg/100ml, p <0.001) and those of triglyceride (TG) were higher (74 and 59mg/100ml for males and females, respectively, p <0.01). There were also no significant differences in HDL-C as a percentage of T-C (32 and 35%) and the LDL-C/HDL-C ratio (2.3 and 2.0). Toc level and the Toc/T-C ratio were significantly lower in males (5.16μg/ml and 3.11μg/mg, respectively) compared with females (6.15μg/ml and 3.46μg/mg, respectively) ( p <0.001 for Toc and p <0.05) for Toc/T-C. A direct relationship was found between the T-C level and LDL-C ( r =0.92, p <0.001) and HDL-C ( r =0.40, p <0.001). The atherogenic index, the LDL-C/HDL-C ratio, showed a positive correlation with the T-C level ( r =0.43, p <0.001) and a negative correlation with the HDL-C level ( r =-0.63, p <0.001). The T-C levels also could be correlated with the levels of Toc ( r =0.37, p <0.001) and inversely correlated with the Toc/T-C ratio ( r =-0.41, p <0.001). The Toc/T-C ratio showed an inverse correlation with the LDL-C/HDL-C ( r= -0.31, p <0.001). These results reveal that the T-C level affects the vitamin E status and that the Toc/T-C ratio can be used to assess trends in CHD risk factors.
关键词：serum lipid status;low density lipoprotein-cholesterol/high density lipoprotein-cholesterol ratio;serum tocopherol status;tocopherol/cholesterol ratio