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标题：Patients with Myasthenia Gravis and Thymoma Have Anti-Skeletal Muscle and Anti-Acetylcholine Receptor Antibodies Simultaneously
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作者：Mitsuhiro OHTA ; Kiyoe OHTA ; Fumiyo MORI 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1989
卷号：6
期号：1
页码：65-75
DOI：10.3164/jcbn.6.65
出版社：The Society for Free Radical Research Japan
摘要：The frequency and mean titer of anti-skeletal muscle (SM) antibody in myasthenic patients with thymoma (64 cases) were significantly high (frequency, 92%; mean titer, 10.1) in all stages of severity, while in myasthenic patients without thymoma (202 cases), they were significantly low (frequency, 24%; mean titer, 2.2). A strong association was found in myasthenic patients between the occurrence of anti-SM antibodies and the presence of thymoma. No correlation was found between titers of anti-SM antibody and those of anti-acetylcholine receptor (AChR) antibody ( r =0.036), although myasthenic patients with thymoma had simultaneously high prevalences of anti-AChR (62/64) and anti-SM (59/64) antibodies. Most of the ocular mysthenic patients with and without thymoma had no or extremely low anti-AChR antibody titers (frequency, 25%, 16/65; mean titer, 1.6pmol/ml). Whereas, in all cases of ocular myasthenic patients with thymoma anti-SM antibodies were significantly high titers (frequency, 100%, 8/8; mean titer, 11.0). Reductions in both anti-AChR and anti-SM antibody titers were observed by the serial measurement after thy(mo)mectomy on most of the 10 myasthenic patients with thymoma. Our data on a large number of myasthenic sera reveal that coexistence of anti-SM and anti-AChR antibodies is strongly linked to myasthenia gravis associated with thymoma. The measurement of anti-SM antibodies is recommended for demonstration of thymoma in myasthenic patients before surgery.
关键词：myasthenia gravis;thymoma;anti-skeletal muscle antibody;anti-acetylcholine receptor antibody;thymectomy