文章基本信息

标题：The effect of astaxanthin on vascular endothelial growth factor (VEGF) levels and peroxidation reactions in the aqueous humor
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作者：Hirotaka Hashimoto ; Kiyomi Arai ; Shimmin Hayashi 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2016
卷号：59
期号：1
页码：10-15
DOI：10.3164/jcbn.15-137
出版社：The Society for Free Radical Research Japan
摘要：We explored the effect of astaxanthin on vascular endothelial growth factor in the aqueous humor, by measuring vascular endothelial growth factor levels and oxidation-related parameters, including O₂^•− scavenging activity, H₂O₂ level, and total hydroperoxide level in the aqueous humor, obtained from 35 patients before and after astaxanthin administration. We evaluated the relationship between vascular endothelial growth factor and the oxidation-related parameters as well as the patient’s diabetic status, age, and sex. Vascular endothelial growth factor levels did not change significantly but O₂^•− scavenging activity and total hydroperoxide level significantly ( p <0.05) increased and decreased, respectively. Both pre- and post- astaxanthin intake, vascular endothelial growth factor and total hydroperoxide levels were positively correlated (Pearson: r = 0.42, p <0.05; r = 0.55, p <0.01, respectively). Analysis of vascular endothelial growth factor levels and O₂^•− scavenging activities gave a negative correlation but only pre-astaxanthin intake (r = −0.37, p <0.05). Differences in levels pre- and post-astaxanthin only showed association between vascular endothelial growth factor and total hydroperoxide (r = 0.49, p <0.01) analyzed by multiple linear regression. Using multivariate analysis, pre-astaxanthin vascular endothelial growth factor level was associated with two factors of total hydroperoxide and O₂^•− scavenging activity (r = 0.49, p <0.05), and post-astaxanthin vascular endothelial growth factor level with two factors of total hydroperoxide and sex (r = 0.60, p <0.01). Astaxanthin intake may have affected vascular endothelial growth factor level through its antioxidant effects by increasing O₂^•− scavenging activity and suppressing peroxide production.
关键词：astaxanthin;aqueous humor;vascular endothelial growth factor;oxidation;superoxide