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标题：Efficiency of Pheophorbide-Dimer in Photodynamic Therapy of Mouse Tumor
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作者：Kunihisa IWAI ; Shuichi KIMURA
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1988
卷号：5
期号：2
页码：145-153
DOI：10.3164/jcbn.5.145
出版社：The Society for Free Radical Research Japan
摘要：We have investigated the efficiency of pheophorbide-dimer (Pheo-dimer) localization into tumors and the effect of photodynamic therapy (PDT) using Pheo-dimer on mice bearing FM3A tumors as a part of our search for new photosensitizers. Pheo-dimer was synthesized by covalently joining two molecules of pyropheophorbide a (Pyro) with an arginine as a cross-link. The in vitro photodynamic inactivation of FM3A cells by Pheo-dimer was less than that by pheophorbide a (Pheo). The FM3A tumor took up Pheo-dimer gradually as well as Pheo, but the time required for localization of Pheo-dimer was faster. The time for attaining the maximum concentration of Pheo in the tumor after injection was 18-24h, while that of Pheo-dimer was 9-12h. A small amount of Pheo-dimer was degraded to monomers by breakage of its cross-link in the body. When irradiation was performed at 10h following administration of Pheo-dimer, the longer survival of mice bearing FM3A tumors was found in comparison with that obtained when Pheo was used. The utility of Pheo-dimer was thus expected in PDT.
关键词：pheophorbide-dimer (Pheo-dimer);photodynamic therapy (PDT);pheophorbide a (Pheo);FM3A tumor