文章基本信息

标题：Improved Sulfatide-Containing Liposomes as Carriers of Adriamyein
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作者：Makoto TAKANO ; Nakao KOJIMA ; Naoki UENO 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1988
卷号：4
期号：3
页码：223-233
DOI：10.3164/jcbn.4.223
出版社：The Society for Free Radical Research Japan
摘要：Various molar ratios of the constituents of sulfatide-containing liposomes (egg phosphatidylcholine, cholesterol, and sulfatide) were examined with respect to liposomal efficiency to entrap adriamycin (ADM) and to the tissue distribution. Among the ratios of the constituents examined, 5:4:1 was the best in terms of entrapment efficiency for both multilamellar vesicles (MLV) and small unilamellar vesicles (SUV). Tissue distribution studies of liposome-entrapped ADM showed that the blood clearance and cardiac uptake of ADM were significantly reduced when the drug was entrapped in the above liposomes, especially in the MLV. Incorporation of ADM into ovarian tumors transplanted into nude mice was increased when the drug was entrapped in the SUV.
关键词：adriamycin;negatively-charged liposomes;sulfatide;tissue distribution;tumor