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标题：Liposome-Entrapped Human Interferon-β
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作者：Kyozo KATO ; Jun YOSHIDA ; Naoki KAGEYAMA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1988
卷号：4
期号：2
页码：139-147
DOI：10.3164/jcbn.4.139
出版社：The Society for Free Radical Research Japan
摘要：Human interferon-β (HuIFN-β) entrapped in liposomes composed of egg phosphatidylcholine, cholesterol, and sulfatide was examined for its antitumor activity against brain tumor cells in vitro and its pharmacokinetics in vivo . HuIFN-β did not lose its biological activity during the preparation of the liposomes. The liposomes entrapped 7-14% of the HuIFN-β used, suggesting that the majority of HuIFN-β was embedded in the liposomal membranes. Cytotoxicity of the liposome-entrapped HuIFN-β against human tumor cells was comparable with that of free HuIFN-β. Intravenous injection of the liposome-entrapped HuIFN-β resulted in higher interferon levels in the blood, liver, spleen, brain, and transplant of human brain tumor, compared with free HuIFN-β. These data show that the liposome-entrapped HuIFN-β should be useful in the treatment of human brain tumors.
关键词：liposomes;sulfatide;interferon;human brain tumor