文章基本信息

标题：Anti-Tumor Effects of Chlorpromazine Derivatives on Yoshida Sarcoma Cells and Ehrlich Ascites Tumor
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作者：Takayuki OZAWA ; Morimitsu NISHIKIMI ; Satoru SUGIYAMA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1988
卷号：4
期号：2
页码：119-122
DOI：10.3164/jcbn.4.119
出版社：The Society for Free Radical Research Japan
摘要：Anti-tumor effect of phenothiazine derivatives is widely recognized. The anti-tumor effects of chlorpromazine derivatives on Yoshida sarcoma cells and Ehrlich ascites tumor were investigated. Derivatives in which Cl of chlorpromazine is replaced with Br and the carbon number of the N-side chain is elongated to 4 or 5 were more effective in anti-tumor action than chlorpromazine. Moreover, their LD₅₀ values were much higher than that of chlorpromazine. From these results, these newly synthesized compounds might be considered for clinical trial.
关键词：chlorpromazine;chlorpromazine derivatives;anti-tumor effect