文章基本信息

标题：Life Span and Oxidative Stress in Nematode
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作者：Naoaki Ishii
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2004
卷号：34
期号：2
页码：61-68
DOI：10.3164/jcbn.34.61
出版社：The Society for Free Radical Research Japan
摘要：The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging and the roles of oxidative stress. In this review we focus on the genetics of select long-lived and short-lived mutants of C. elegans that have proven useful in revealing the relationships that exist between oxidative stress and life span. The former are known to be controlled by an insulin/insulin-like growth factor (IGF-1)-like pathway, while the latter are affected by mitochondrial functions.
关键词：nematodes;oxidative stress;life span;insulin/IGF-1-like signal pathway;mitochondria