文章基本信息

标题：Preferential Mesenteric Fat Accumulation and Enhanced Portal Free Fatty Acid Delivery in a High-Carbohydrate Diet Fed Rats
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作者：Yoko Shirai ; Masashige Suzuki
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2003
卷号：33
期号：2
页码：53-59
DOI：10.3164/jcbn.33.53
出版社：The Society for Free Radical Research Japan
摘要：The regulation of adipose tissue distribution is an important problem in view of the close epidemiological and metabolic associations between centralized fat accumulation and disease. However, the majority of studies concerning adipose tissue distribution and metabolic disorders have focused on subjects already being obese. In this study, the effects of a high-carbohydrate diet (CHO) and a high-fat diet (FAT) on mass and function of mesenteric adipose depot, drained by the mesenteric vein, was examined in the pre-obese rat model. After 4 weeks of iso-energy feeding, the ratio of mesenteric adipose tissue weight to non-mesenteric was significantly greater in the CHO-fed group than in the FAT-fed group. Incorporation of orally administrated ³H-glucose into the mesenteric depot was more rapid in the CHO-fed group than in the FAT-fed group, but its incorporation into the non-mesenteric depot was similar between the two dietary groups. Arterial and mesenteric concentrations of free fatty acid and triglyceride of the CHO-fed group were significantly higher than those of the FAT-fed group. Gene expression of PPAR-γ and UCP-2 was similar among adipose depots, and there was no significant difference between the two dietary groups. In conclusion, dietary carbohydrate was preferentially incorporated into the total lipid in mesenteric adipose tissue. Without an increase in total body fat, CHO feeding for 4 weeks reinforces incorporation of dietary glucose into mesenteric depot, resulting in an increases of relative mesenteric adipose mass and portal FFA delivery.
关键词：mesenteric fat;portal free fatty acid;dietary carbohydrate;lipogenesis