文章基本信息

标题：Anti-Acetylcholine Receptor Antibody in Myasthenia Gravis
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作者：Fumiyo MATSUBARA-MORI ; Mitsuhiro OHTA ; Kiyoe OHTA 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：1987
卷号：3
期号：3
页码：265-275
DOI：10.3164/jcbn.3.265
出版社：The Society for Free Radical Research Japan
摘要：Levels of anti-acetylcholine receptor (AChR) antibodies were investigated in sera of 272 patients with myasthenia gravis (MG) and 75 patients with other autoimmune diseases by the immunoprecipitation method (RIA) using rat denervated muscle AChR as an antigen. Anti-AChR antibodies were found in over 70% of the MG patients but not in those with other autoimmune diseases except for only 2 cases with border-line titer. Most patients with ocular MG without thymoma had insignificant levels of antibody titers. In patients with generalized MG, both the mean values of antibody titer and percentages positive for the antibody were roughly correlated with clinical seventies. Antibody titers and clinical features were estimated for a long-term period on MG patients who underwent thymectomy (24 cases with thymoma and 48 cases without thymoma). After the operation, anti-AChR antibody levels tended to decrease significantly, corresponding to the clinical improvement; moreover, patients with thymic hyperplasia showed better clinical improvement than those with thymoma.
关键词：anti-acetylcholine receptor antibody;myasthenia gravis;thymectomy;thymoma;autoimmune disease